Doctors must also be careful about possible conflicts between medications for bipolar symptoms and medications used for other purposes. Both Johnson and Haas hope that people will see detox as more than just a two- or three-week-long effort and incorporate the body-cleansing ideas into daily habits. While the detox diet is heavy on fiber, it’s light on protein. But it’s intentionally so, Haas says, because most Americans consume more protein than necessary — especially the animal kind — and a break is usually welcome, he says. Or take milk thistle extract, another popular detox or cleansing supplement.

Certain people should not start any detox or calorie-restricting regimens without consulting a doctor first. Furthermore, colon cleansing methods, which are sometimes recommended during detoxes, can cause dehydration, cramping, bloating, nausea, and vomiting . On top of that, crash diets can be a stressful experience, as they involve resisting temptations and feeling extreme hunger . That said, many people also report feeling very unwell during the detox period.